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cenobamate will increase the amount or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Keep an eye on Closely. Take into account a dose reduction of CYP2C19 substrates, as clinically ideal, when utilised concomitantly with cenobamate.Result of coadministration of a twin CYP3A4 and CYP2C19 inhibitor with fedratinib